From My Personal Collection:

What do Marvel heroes do when they're not fighting super villains? Combat the dangers of smoking of course! In 1982 and again in 1991 The American Cancer Society teamed up with Marvel comics to release a free issue where Spider-Man, Powerman, and Storm fight Smokescreen, a villain who is trying to get a high school track star to smoke. Turns out the Mob is betting on the next track meet and are trying to get him to smoke to rig it. And you were worried they were killing people and smuggling Cocaine into the country.